Cytoplasmic retention signal
WebApr 8, 2014 · When present within 4-residues of the TMD it serves as a Golgi export signal, but when located at the C-terminus of the 68-residue p14 cytoplasmic endodomain it functions as an ER retention signal. The PBM has no effect on protein trafficking when located at an internal position in the cytoplasmic domain. WebSep 1, 1994 · Although the cytoplasmic retention signal region is outside the cyclin box, its sequence is well conserved in human cyclin B2, and is both necessary and sufficient to keep cyclin B2 in the cytoplasm.
Cytoplasmic retention signal
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WebThe N- terminal signal/anchor of cytochrome P450 2C1 functioned as an ER retention signal when placed at the N terminus of several reporter proteins but not when fused at the C terminus of the extracellular domain of epidermal growth factor receptor, with or without a heterologous cytoplasmic domain. WebThis new understanding of the determinants of nuclear retention and cytoplasmic export provides a deeper understanding of how information flow is regulated in eukaryotic cells. Ultimately these processes promote …
WebOct 13, 1995 · The N-terminal signal/anchor of cytochrome P450 2C1 functioned as an ER retention signal when placed at the N terminus of several reporter proteins but not … WebJan 12, 2024 · The cytoplasmic tail is still not well known but contains an ER retrieval signal that is shared by other similar viruses. ... of the cell by as yet unknown retention …
WebAug 1, 1997 · Although JNK is located in both the cytoplasm and the nucleus of quiescent cells, activation of JNK is associated with accumulation of JNK in the nucleus ( 8 ). … WebOct 19, 2005 · Distribution of YB-1 between the nucleus and the cytoplasm is known to be dependent on nuclear targeting and cytoplasmic retention signals located within the C-terminal portion of YB-1.
ER retention refers to proteins that are retained in the endoplasmic reticulum, or ER, after folding; these are known as ER resident proteins. Protein localization to the ER often depends on certain sequences of amino acids located at the N terminus or C terminus. These sequences are known as signal peptides, molecular signatures, or sorting signals.
WebThe ER retention signal of the cytoplasmic domain could not be localized to a single amino acid segment by deletion analysis. These results show that cytochrome P450 2C2 … chipotle newark delawareWebNov 12, 2004 · Here we report that the cytoplasmic localization of hHDAC6 is resistant to treatment with leptomycin B (LMB), demonstrate that the SE14 repeat domain is responsible for this resistance, and show that hHDAC6 possesses intrinsic … chipotle newark caWebAug 1, 1999 · studies provide evidence for a cytoplasmic targeting/retention signal (CTRS) in MA that is responsible for intracytoplasmic capsid assembly in Type D retroviruses. chipotle new bern ncWebJul 18, 2008 · The cytoplasmic tails play a role in the localization of glycosyltransferases, and coat protein complex I (COPI) vesicle–mediated retrograde transport is also involved … chipotle newarkWebNov 6, 2024 · In this study, we identified that the glycophorin transmembrane domain encoded an ER/Golgi retention signal, which could be counteracted by forward-trafficking signals (i.e., the R18 epitope of GPA/GP.Mur; the cytoplasmic domain of GPA ) … chipotle net worth 2021WebOct 13, 1995 · The ER retention signal of the cytoplasmic domain could not be localized to a single amino acid segment by deletion analysis. These results show that cytochrome P450 2C2 contains redundant, complex ER retention signals in its cytoplasmic and N-terminal hydrophobic domains and that the function of the N-terminal signal is context … gran turismo playstation.comWebcdc25C is a phosphatase, which activates the mitosis-promoting factor cyclin B1/cdc2 by dephosphorylation, and thus triggers G2/M transition. The activity of cdc25C itself is controlled by phosphoryl chipotle newberg oregon