Cisplatin anticancer mechanism
WebAim: To investigate the synergetic effect and the mechanism of antitumor action of the antibiotic lidamycin in combination with cisplatin in vitro. Methods: Cytotoxicity of the drugs was measured by clonogenic assay. Chromatin condensation was observed by co-staining with fluorescent dyes, Hoechst 33342 and propidium iodide. Apoptotic sub-G1 was … WebNov 24, 2024 · 1.1. Lung Cancer. Among all forms of cancer, lung cancer is the leading cause of mortality worldwide [1, 2]. Despite advances in development of new treatment modalities, the overall 5-year survival rate has only slightly increased over 2.5 decades, remaining at approximately 16% [4, 5].Early diagnostic procedures and hits, and effective …
Cisplatin anticancer mechanism
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WebNov 2, 2024 · Among other cancers, cisplatin is used as a first-line treatment for: leukemia lymphoma breast cancer testicular cancer ovarian cancer head and neck cancer cervical … WebCisplatin (DDP) is a common therapeutic option for non‐small cell lung carcinoma (NSCLC). However, some patients fail to respond to the DDP chemotherapy. ... 36 The main anticancer molecular mechanisms of DDP include: (1) induction of oxidative stress characterized by reactive oxygen species and lipid peroxidation; (2) ...
WebThe mechanism of action of cisplatin has been associated with ability to crosslink with the urine bases on the DNA to form DNA adducts, preventing repair of the DNA leading to … WebJun 26, 2024 · The cytotoxic action of cisplatin is conditioned by the covalent binding of this molecule to N-7 purine atoms on high affinity DNA, which leads to the cross-link of DNA strands and inhibition of...
Web2 days ago · Cisplatin is used successfully in the chemotherapy of testicular cancer. However, patients who develop resistance to the cytostatic drug urgently need … WebA New Molecular Mechanism of Cisplatin Resistance A very recent investigation demonstrated a new mechanism by which the oncoprotein c-Myc enables cancer cells …
WebCisplatin exerts anticancer activity via multiple mechanisms but its most acceptable mechanism involves generation of DNA lesions by interacting with purine bases on DNA …
WebCisplatin is approved to be used alone or with other drugs to treat: Bladder cancer. It is used alone in patients with advanced cancer that cannot be treated with other therapies, … iphone 12 pro veryWebMar 15, 2011 · Numerous mechanisms of cisplatin resistance were described including changes in cellular uptake, drug efflux, increased detoxification, inhibition of apoptosis and increased DNA repair. To minimize cisplatin resistance, combinatorial therapies were developed and have proven more effective to defeat cancers. iphone 12 pro vs iphoneWebJun 20, 2024 · Cisplatin [cis-diamminedichloroplatinum(II) (cis-DDP)] is one of the most successful anticancer agents employed today and is effective against a wide range of … iphone 12 pro v iphone 13WebCisplatin enters the cell either passively or through a transporter, where two water molecules replace the chloride groups. As an electrophile, cisplatin is attracted to the nitrogen on purine bases in the DNA, where it forms inter or intra-strand crosslinks, interrupting DNA repair and replication processes. iphone 12 pro wallet case tucchiphone 12 pro vs mirrorless cameraWeb1152 rows · Jun 13, 2005 · Cisplatin is a platinum based chemotherapy agent used to treat various sarcomas, carcinomas, lymphomas, and germ cell tumors. Brand Names. … iphone 12 pro vs iphone 12WebApr 12, 2012 · Cisplatin exerts anticancer effects via multiple mechanisms, yet its most prominent (and best understood) mode of action involves the generation of DNA lesions followed by the activation of the DNA damage response … iphone 12 pro vs iphone xr